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According to a “Swiss Army Knife” model of the brain, cognitive functions such as episodic memory and face perception map onto distinct neural substrates. In contrast, representational accounts propose that each brain region is best explained not by which specialized function it performs, but by the type of information it represents with its neural firing. In a functional magnetic resonance imaging study, we asked whether the neural signals supporting recognition memory fall mandatorily within the medial temporal lobes (MTL), traditionally thought the seat of declarative memory, or whether these signals shift within cortex according to the content of the memory. Participants studied objects and scenes that were unique conjunctions of pre-defined visual features. Next, we tested recognition memory in a task that required mnemonic discrimination of both simple features and complex conjunctions. Feature memory signals were strongest in posterior visual regions, declining with anterior progression toward the MTL, while conjunction memory signals followed the opposite pattern. Moreover, feature memory signals correlated with feature memory discrimination performance most strongly in posterior visual regions, whereas conjunction memory signals correlated with conjunction memory discrimination most strongly in anterior sites. Thus, recognition memory signals shifted with changes in memory content, in line with representational accounts.

 

Cystic fibrosis (CF) is characterized by chronic respiratory infections which progressively decrease lung function over time. Affected individuals experience episodes of intensified respiratory symptoms called pulmonary exacerbations (PEx), which in turn accelerate pulmonary function decline and decrease survival rate. An overarching challenge is that there is no standard classification for PEx, which results in treatments that are heterogeneous. Improving PEx classification and management is a significant research priority for people with CF. Previous studies have shown volatile organic compounds (VOCs) in exhaled breath can be used as biomarkers because they are products of metabolic pathways dysregulated by different diseases. To provide insights on PEx classification and other CF clinical factors, exhaled breath samples were collected from 18 subjects with CF, with some experiencing PEx and others serving as a baseline. Exhaled breath was collected in Tedlar bags during tidal breathing and cryotransferred to headspace vials for VOC analysis by solid phase microextraction coupled to gas chromatography–mass spectrometry. Statistical significance testing between quantitative and categorical clinical variables displayed percent-predicted forced expiratory volume in one second (FEV1pp) was decreased in subjects experiencing PEx. VOCs correlating with other clinical variables (body mass index, age, use of highly effective modulator treatment (HEMT), and the need for inhaled tobramycin) were also explored. Two volatile aldehydes (octanal and nonanal) were upregulated in patients not taking the HEMT. VOCs correlating to potential confounding variables were removed and then analyzed by regression for significant correlations with FEV1pp measurements. Interestingly, the VOC with the highest correlation with FEV1pp (3,7-dimethyldecane) also gave the lowestp-value when comparing subjects at baseline and during PEx. Other VOCs that were differentially expressed due to PEx that were identified in this study include durene, 2,4,4-trimethyl-1,3-pentanediol 1-isobutyrate and 5-methyltridecane. Receiver operator characteristic curves were developed and showed 3,7-dimethyldecane had higher ability to classify PEx (area under the curve (AUC) = 0.91) relative to FEV1pp values at collection (AUC = 0.83). However, normalized ΔFEV1pp values had the highest capability to distinguish PEx (AUC = 0.93). These results show that VOCs in exhaled breath may be a rich source of biomarkers for various clinical traits of CF, including PEx, that should be explored in larger sample cohorts and validation studies.

 

Abstract We present mid-infrared spectroscopic observations of the nucleus of the nearby Seyfert galaxy NGC 7469 taken with the MIRI instrument on the James Webb Space Telescope (JWST) as part of Directors Discretionary Time Early Release Science program 1328. The high-resolution nuclear spectrum contains 19 emission lines covering a wide range of ionization. The high-ionization lines show broad, blueshifted emission reaching velocities up to 1700 km s −1 and FWHM ranging from ∼500 to 1100 km s −1 . The width of the broad emission and the broad-to-narrow line flux ratios correlate with ionization potential. The results suggest a decelerating, stratified, AGN-driven outflow emerging from the nucleus. The estimated mass outflow rate is 1–2 orders of magnitude larger than the current black hole accretion rate needed to power the AGN. Eight pure rotational H 2 emission lines are detected with intrinsic widths ranging from FWHM ∼125 to 330 km s −1 . We estimate a total mass of warm H 2 gas of ∼1.2 × 10 7 M ⊙ in the central 100 pc. The PAH features are extremely weak in the nuclear spectrum, but a 6.2 μ m PAH feature with an equivalent width of ∼0.07 μ m and a flux of 2.7 × 10 −17 W m −2 is detected. The spectrum is steeply rising in the mid-infrared, with a silicate strength of ∼0.02, significantly smaller than seen in most PG QSOs but comparable to other Seyfert 1s. These early MIRI mid-infrared IFU data highlight the power of JWST to probe the multiphase interstellar media surrounding actively accreting supermassive black holes. 

We present the analysis of ∼100 pc scale compact radio continuum sources detected in 63 local (ultra)luminous infrared galaxies (U/LIRGs;L_IR≥ 10¹¹L_⊙), using FWHM ≲ 0.″1–0.″2 resolution 15 and 33 GHz observations with the Karl G. Jansky Very Large Array. We identify a total of 133 compact radio sources with effective radii of 8–170 pc, which are classified into four main categories—“AGN” (active galactic nuclei), “AGN/SBnuc” (AGN-starburst composite nucleus), “SBnuc” (starburst nucleus), and “SF” (star-forming clumps)—based on ancillary data sets and the literature. We find that “AGN” and “AGN/SBnuc” more frequently occur in late-stage mergers and have up to 3 dex higher 33 GHz luminosities and surface densities compared with “SBnuc” and “SF,” which may be attributed to extreme nuclear starburst and/or AGN activity in the former. Star formation rates (SFRs) and surface densities (Σ_SFR) are measured for “SF” and “SBnuc” using both the total 33 GHz continuum emission (SFR ∼ 0.14–13M_⊙yr⁻¹, Σ_SFR∼ 13–1600M_⊙yr⁻¹kpc⁻²) and the thermal free–free emission from Hiiregions (median SFR_th∼ 0.4M_⊙yr⁻¹,${\mathrm{\Sigma }}_{{\mathrm{SFR}}_{\mathrm{th}}}\sim 44M_{\odot }$yr⁻¹kpc⁻²). These values are 1–2 dex higher than those measured for similar-sized clumps in nearby normal (non-U/LIRGs). The latter also have a much flatter median 15–33 GHz spectral index (∼−0.08) compared with “SBnuc” and “SF” (∼−0.46), which may reflect higher nonthermal contribution from supernovae and/or interstellar medium densities in local U/LIRGs that directly result from and/or lead to their extreme star-forming activities on 100 pc scales.

 

We present results from the James Webb Space Telescope Director’s Discretionary Time Early Release Science program 1328 targeting the nearby, luminous infrared galaxy, VV 114. We use the MIRI and NIRSpec instruments to obtain integral-field spectroscopy of the heavily obscured eastern nucleus (V114E) and surrounding regions. The spatially resolved, high-resolution spectra reveal the physical conditions in the gas and dust over a projected area of 2–3 kpc that includes the two brightest IR sources, the NE and SW cores. Our observations show for the first time spectroscopic evidence that the SW core hosts an active galactic nucleus as evidenced by its very low 6.2μm and 3.3μm polycyclic aromatic hydrocarbon equivalent widths (0.12 and 0.017μm, respectively) and mid- and near-IR colors. Our observations of the NE core show signs of deeply embedded star formation including absorption features due to aliphatic hydrocarbons, large quantities of amorphous silicates, as well as HCN due to cool gas along the line of sight. We detect elevated [Feii]/Pfαconsistent with extended shocks coincident with enhanced emission from warm H₂, far from the IR-bright cores and clumps. We also identify broadening and multiple kinematic components in both H₂and fine structure lines caused by outflows and previously identified tidal features.

 

ABSTRACT The merger of two or more galaxies can enhance the inflow of material from galactic scales into the close environments of active galactic nuclei (AGNs), obscuring and feeding the supermassive black hole (SMBH). Both recent simulations and observations of AGN in mergers have confirmed that mergers are related to strong nuclear obscuration. However, it is still unclear how AGN obscuration evolves in the last phases of the merger process. We study a sample of 60 luminous and ultra-luminous IR galaxies (U/LIRGs) from the GOALS sample observed by NuSTAR. We find that the fraction of AGNs that are Compton thick (CT; $N_{\rm H}\ge 10^{24}\rm \, cm^{-2}$) peaks at $74_{-19}^{+14}{{\ \rm per\ cent}}$ at a late merger stage, prior to coalescence, when the nuclei have projected separations (dsep) of 0.4–6 kpc. A similar peak is also observed in the median NH [$(1.6\pm 0.5)\times 10^{24}\rm \, cm^{-2}$]. The vast majority ($85^{+7}_{-9}{{\ \rm per\ cent}}$) of the AGNs in the final merger stages (dsep ≲ 10 kpc) are heavily obscured ($N_{\rm H}\ge 10^{23}\rm \, cm^{-2}$), and the median NH of the accreting SMBHs in our sample is systematically higher than that of local hard X-ray-selected AGN, regardless of the merger stage. This implies that these objects have very obscured nuclear environments, with the $N_{\rm H}\ge 10^{23}\rm \, cm^{-2}$ gas almost completely covering the AGN in late mergers. CT AGNs tend to have systematically higher absorption-corrected X-ray luminosities than less obscured sources. This could either be due to an evolutionary effect, with more obscured sources accreting more rapidly because they have more gas available in their surroundings, or to a selection bias. The latter scenario would imply that we are still missing a large fraction of heavily obscured, lower luminosity ($L_{2-10}\lesssim 10^{43}\rm \, erg\, s^{-1}$) AGNs in U/LIRGs. 

Local galaxies from the Sloan Digital Sky Survey (SDSS) are used to provide additional support for an evolutionary pathway in which active galactic nucleus activity is associated with star formation quenching. Composite, Seyfert 2, and LINER galaxies account for ∼60 per cent of all star formation in massive galaxies (M⋆ > 1010.5 M⊙). Inclusion of these galaxies results in a ‘turnover’ in the star formation rate and stellar mass (SFR−M⋆) relation for massive galaxies. Our analysis shows that bulge growth has already occurred in the most massive galaxies (M⋆ > 1010.5 M⊙), and bulges continue to grow as galaxies quench and redden, (g − r)  = 0.5 → 0.75. Significant bulge growth is also occurring in low mass starburst galaxies (M⋆ < 1010.5 M⊙) at 0.5 dex above the ‘main sequence’ (MS), where we find an increase in B/T from 0.1 → 0.3 and bluer colours, (g − r) < 0.25 compared to low-mass galaxies on the MS.

 

Abstract The Cosmic Evolution Survey (COSMOS) has become a cornerstone of extragalactic astronomy. Since the last public catalog in 2015, a wealth of new imaging and spectroscopic data have been collected in the COSMOS field. This paper describes the collection, processing, and analysis of these new imaging data to produce a new reference photometric redshift catalog. Source detection and multiwavelength photometry are performed for 1.7 million sources across the 2 deg 2 of the COSMOS field, ∼966,000 of which are measured with all available broadband data using both traditional aperture photometric methods and a new profile-fitting photometric extraction tool, The Farmer , which we have developed. A detailed comparison of the two resulting photometric catalogs is presented. Photometric redshifts are computed for all sources in each catalog utilizing two independent photometric redshift codes. Finally, a comparison is made between the performance of the photometric methodologies and of the redshift codes to demonstrate an exceptional degree of self-consistency in the resulting photometric redshifts. The i < 21 sources have subpercent photometric redshift accuracy and even the faintest sources at 25 < i < 27 reach a precision of 5%. Finally, these results are discussed in the context of previous, current, and future surveys in the COSMOS field. Compared to COSMOS2015, it reaches the same photometric redshift precision at almost one magnitude deeper. Both photometric catalogs and their photometric redshift solutions and physical parameters will be made available through the usual astronomical archive systems (ESO Phase 3, IPAC-IRSA, and CDS).